We typically recommend 1 treat daily. For dogs under 25lbs, start with half a treat (2.5mg), For dogs over 25lbs start with one full treat (5mg). Note: Metabolism plays a key role in consumption. Monitor your pups response to the dosage and adjust accordingly. (ex. If you do not see noticeable difference in your pups demeanor within 20-30 min, try upping the dose.) It is safe to double or triple dose. YUP™ to Salmon Dog Treats.